Genotoxic activity of betel nut on germinal cell in Sarcoma 180 ascites tumour bearing male mice

The genotoxicity of the ethanolic extract betel nut was evaluated using sarcoma 180 tumour bearing mouse considering sperm motility, viability, biochemical estimation fructose in seminal fluid and head morphology assays. Sperm studied by H-E staining Toluidine blue method. But method is a reliable to evaluate DNA damage sperms. Ethanolic BNE (betel extract) can suppress percentage viability level. In addition, it also enhance damaged Moreover, histological sections testes have been control treated mice highlight potential toxic effect BNE. significant decreasing rate concentration, motility as well increasing abnormality different doses series may be result alkaloid ingredients present Therefore, results showed induce types germ cell abnormalities male mice.